Much like guitars in general, you may come across one that's as good as a vintage or Custom Shop?
I always like picking up Road Worn strats and teles just for fun at guitar stores. The necks feel good, but the consistency from guitar to guitar is spotty. 9 times out of 10, they sound acoustically dead or have fret out spots on the neck, unlike a guitar 3 times it's price. Then you pick up one that rings loud and has a perfect neck and setup.
I've generally had the best luck with the sunburst strat w/rosewood and the sunburst tele w/maple. Most gems I've picked up are those. If I ever did get one, I'd put a Callaham bridge on it, along with better pickups and strung w/11's. Then, it'd really be something.
Today, I played a $900 Road worn tele w/maple that's probably the only MIM $900 guitar I'd buy, if I were actually shopping for real.
It looked just like this one.