For almost two decades, I always used whatever wiring came with my American Fender strats, and usually just changed the pickups. I usually use them with the bridge/middle tone turned down to 8 and the neck always up.
I always lived with the Fender flaw of having the middle pickup connected to the bridge tone, so the 2nd and 4th positions would also have the middle turned to 8.
Then, along came my discovery of the Eric Johnson wiring diagram a few years ago. All you do is move the wires around on the 5 way switch, and you've got volume, neck tone, and bridge tone. The middle isn't effected by either tone control.
How sensible is that??? That's the way a strat should have been wired to begin with.
I've tried a couple others over the years, but didn't like blending bridge and neck like a lot of players use. I just like the standard switching, but the Eric Johnson wiring is ideal for me.
So, what type of strat wiring are you using?
Here's some decent pics I found of the mod.