I'm sure this is a common problem, especially with 24.75" scale guitars, but is it at all possible to achieve perfect (if not at LEAST satisfactory) intonation when using low tunings? I don't have too much of an issue with the 1st thru 5th strings, but the 6th string is a bugger! Even after flipping the bridge saddle around on both of my guitars (both tune-o-matic equipped), I still don't have enough room to get it spot-on. It's SO close, but even if others don't notice it when I'm playing, it drives me NUTS just knowing that it's not right.
One thing with which I haven't experimented much is the height of the tailpiece. I know basically that it is there in order to achieve the proper downward angle across the bridge, but I'm sure it is at least a factor in overall intonation, and possibly string tension as well.
I'm open to any suggestions you guys may have that are experienced with these type of bridge/tailpiece/intonation dilemmas.