Yes Seymour Duncan humbuckers are compatible with the PRS-type 5 way switching. If you are replacing the bridge pickup, the magnet will first need to be flipped to correct phase issues related to the parallel wiring and series coils between two split humbuckers that is utilized in the PRS 5 way switching. The Seymour Duncan humbucker will also need to be wired differently from the way it is usually wired into a guitar. The hot lead will be the white wire from the Seymour Duncan humbucker, the black and green wires will be connected together and the red lead will be ground. PRS wiring is white=hot, red=split and black=ground so use these codes to install your Seymour Duncan pickup.