I noticed that when playing with the extreme distortion a fuzz gives you, the single coils may sound better to me than the humbuckers (with more definition.)
But it also depends on the guitar.
3 main guitars : Jeff Beck Strat v1 (baseball neck & Lace Sensors) / 1978 Deluxe Telecaster (Wide Range & diving headstock), 1968 SG Standard with 2018 frets (SH-6 / P-Rail)
Guitars with specific purpose : Slide in E or open G, Baritone, 12 strings, open C / C# Slide, high-strung Nashville...
I had the pleasure of talking with Steve Lukather at NAMM last year. I asked him about what he thinks makes great tone and he said it all comes from your fingers. I doesn't matter what rig you play, tone starts with the player. If you put Eddie on your rig, he will sound like Eddie. I tend to agree. 90% of tone comes from you and your playing style.
The Gear:
1995 Gibson SG, 1991 Gibson Lucille, 2005 Fender Strat Custom, 1989 Ibanez Jem, And many more....
"It is true. I never practice guitar or take guitar lessons. From time to time I open the case and throw in a piece of raw meat."
-Wes Montgomery