General Tone Tips

[Gtrjunior]

When playing through a plexi Marshall circuit, you'll probably find that turning the bass down to 1 or 2 works very well... and even with the bass completely off.

With my JCM 800 I turn the treble all the way off and bring in the high end with the presence control!!

[Francois]

I noticed that when playing with the extreme distortion a fuzz gives you, the single coils may sound better to me than the humbuckers (with more definition.)
But it also depends on the guitar.